Symbol
Name
ID

Nos3
nitric oxide synthase 3, endothelial cell
MGI:97362

Phenotype annotations related to reproductive system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Epididymitis	Prostate cancer	Absent vas deferens	Dysgerminoma	Ovarian papillary adenocarcinoma	Genital ulcers	Priapism	Male infertility
Disease(s) Associated with NOS3	Epididymitis	Prostate cancer	Absent vas deferens	Dysgerminoma	Ovarian papillary adenocarcinoma	Genital ulcers	Priapism	Male infertility
Behcet's disease
cystic fibrosis
ovarian cancer
prostate cancer
sickle cell anemia

Mouse Phenotypes

reproductive system phenotype

abnormal oocyte morphology

abnormal primary polar body morphology

abnormal ovary morphology

decreased corpora lutea number

small ovary

abnormal ovary physiology

early reproductive senescence

abnormal female meiosis

abnormal oogenesis

abnormal epididymis morphology

enlarged epididymis

delayed female fertility

abnormal penile erection

abnormal superovulation

decreased superovulation rate

anovulation

decreased ovulation rate

prolonged diestrus

prolonged estrous cycle

short estrous cycle

abnormal pregnancy

impaired embryo implantation

reduced female fertility

abnormal fertility/fecundity

decreased litter size

impaired fertilization

decreased fertilization frequency

abnormal ejaculation

Availability

Mouse Genotype

Nos3^em1(IMPC)Mbp/Nos3^em1(IMPC)Mbp

Nos3^tm1Plh/Nos3^tm1Plh

Nos3^tm1Unc/Nos3^tm1Unc

Nos3^tm1Weo/Nos3^tm1Weo

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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